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There’s only one place in America where historic Route 66 meets the Great River Road – just outside St. Louis in the Great Rivers & Routes region of Southwest Illinois. From the majestic confluence of the Missouri, Mississippi, and Illinois rivers to walking in the footsteps of Lewis & Clark and Lincoln to the miners, mobsters, and characters who infuse the small towns along Route 66, create an itinerary that will capture and delight your travelers. Download our Destination Guide for more information.

Conveniently located just 20 minutes from St. Louis Lambert International Airport, the area is easily accessible via I-55, I-70, I-270, I-44, I-255 and I-64. Travel by train from all over the country and pull into the Amtrak station located in Alton.

The Great Rivers & Routes Tourism Bureau is at your service. Our sales team will collect hotel quotes, create a customized itinerary, schedule attraction and museum reservations, provide group-friendly dining options and supply welcome bags for your attendees.

With more than 50 group-friendly attractions and over 40 full-service and limited service hotels and motels in the region, you will find the perfect fit for your group size and budget.

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