After a long day of exploring the Great Rivers & Routes region, you’re going to want a place to relax and rest up before your next adventure.

Lodging in the region ranges from high-end hotel stays to camping and RV sites surrounded by Mother Nature. The area has more than 40 full-service and limited service hotels, motels and other lodging options with a total of 3,100 rooms available.

Want a more personal experience? We’ve got a number of bed & breakfast spots waiting for you.

Aiming to stay a little longer? Vacation rentals dot the banks of the Mississippi River, especially in Grafton and Alton.

Browse our lodging listings for the complete roundup of hotels, cabins and more.